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Simultaneous PET/MRI in stroke: a case series.

ABSTRACT: Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis >4.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this was partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases of simultaneous [(15)O]H2O-positron emission tomography (PET)/MRI in stroke patients and an ovine model. Discrepancies between simultaneously obtained PET and MRI readouts were observed that might explain the above current limitations of stroke MRI. By offering highly complementary information, [(15)O]H2O-PET/MRI might help to identify critically hypoperfused tissue resulting in an improved patient stratification in thrombolysis trials.

SUBMITTER: Werner P 

PROVIDER: S-EPMC4640332 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Simultaneous PET/MRI in stroke: a case series.

Werner Peter P   Saur Dorothee D   Zeisig Vilia V   Ettrich Barbara B   Patt Marianne M   Sattler Bernhard B   Jochimsen Thies T   Lobsien Donald D   Meyer Philipp M PM   Bergh Florian Then FT   Dreyer Antje A   Boltze Johannes J   Classen Joseph J   Fritzsch Dominik D   Hoffmann Karl-Titus KT   Sabri Osama O   Barthel Henryk H  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150715 9

Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis >4.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this was partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases of simultaneous [(15)O]H2O-positron emission tomography (PET)/MRI in stroke patients and an ovine model. Discrepancies between simultaneously obtained PET and MRI readout  ...[more]