Association between a vascular endothelial growth factor gene polymorphism (rs2146323) and diabetic retinopathy: a meta-analysis.

ABSTRACT:

Background

Vascular endothelial growth factor (VEGF) is thought to play an important role in the pathogenesis of diabetic retinopathy (DR). Previous studies have associated the VEGF rs2146323 polymorphism with the risk of DR. However, the results of these studies are inconsistent. A meta-analysis was performed to evaluate the association between the VEGF rs2146323 polymorphism and the risk of DR.

Methods

The PubMed, EMBASE, Web of Science and Google Scholar literature databases until March 2015 were searched. The differences in the studies were expressed in the form of an odds ratio (OR) and the corresponding 95% confidence interval (CI). Heterogeneity among the studies was tested using the I(2) statistic based on the Q test.

Results

A total of four studies (598 cases

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC4640352 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature