RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.

ABSTRACT: We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ levels in brain, biochemical analysis strongly suggested improved clearance of soluble Aβ, including Aβ oligomers. To get further insight into molecular mechanisms underlying this therapeutic effect, we explored genome-wide differential gene expression in brain of bexarotene and control treated APP/PS1 mice. We performed high throughput massively parallel sequencing on mRNA libraries generated from cortices of bexarotene or vehicle treated APP/PS1 mice and compared the expression profiles for differential gene expression. Gene Ontology (GO) Biological Process categories with the highest fold enrich

SUBMITTER: Lefterov I 

PROVIDER: S-EPMC4640940 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature