A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.

ABSTRACT:

Background

Bipolar disorder is a heterogeneous mood disorder associated with several important clinical comorbidities, such as eating disorders. This clinical heterogeneity complicates the identification of genetic variants contributing to bipolar susceptibility. Here we investigate comorbidity of eating disorders as a subphenotype of bipolar disorder to identify genetic variation that is common and unique to both disorders.

Methods

We performed a genome-wide association analysis contrasting 184 bipolar subjects with eating disorder comorbidity against both 1370 controls and 2006 subjects with bipolar disorder only from the Bipolar Genome Study (BiGS).

Results

The most significant genome-wide finding was observed bipolar with comorbid eating disorder vs. controls with

SUBMITTER: Liu X 

PROVIDER: S-EPMC4640946 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature