Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts.

ABSTRACT:

Background

Long-term intermittent oral corticosteroid (OCS) use in children with asthma leads to significant decreases in bone mineral accretion (BMA).

Objective

We aimed to identify genetic factors influencing OCS dose effects on BMA in children with asthma.

Methods

We first performed a gene-by-OCS interaction genome-wide association study (GWAS) of BMA in 489 white participants in the Childhood Asthma Management Program trial who took short-term oral prednisone bursts when they experienced acute asthma exacerbations. We selected the top-ranked 2000 single nucleotide polymorphisms (SNPs) in the GWAS and determined whether these SNPs also had cis-regulatory effects on dexamethasone-induced gene expression in osteoblasts.

Results

We identified 2 SNPs (rs9896933

SUBMITTER: Park HW 

PROVIDER: S-EPMC4641004 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature