Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.

ABSTRACT:

Importance

Mutations in known causal Alzheimer disease (AD) genes account for only 1% to 3% of patients and almost all are dominantly inherited. Recessive inheritance of complex phenotypes can be linked to long (>1-megabase [Mb]) runs of homozygosity (ROHs) detectable by single-nucleotide polymorphism (SNP) arrays.

Objective

To evaluate the association between ROHs and AD in an African American population known to have a risk for AD up to 3 times higher than white individuals.

Design, setting, and participants

Case-control study of a large African American data set previously genotyped on different genome-wide SNP arrays conducted from December 2013 to January 2015. Global and locus-based ROH measurements were analyzed using raw or imputed genotype data. We studied th

SUBMITTER: Ghani M 

PROVIDER: S-EPMC4641052 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature