Optimum population-level use of artemisinin combination therapies: a modelling study.

ABSTRACT:

Background

Artemisinin combination therapies (ACTs) are used worldwide as first-line treatment against confirmed or suspected Plasmodium falciparum malaria. Despite the success of ACTs at reducing the global burden of malaria, emerging resistance to artemisinin threatens these gains. Countering onset of resistance might need deliberate tactics aimed at slowing the reduction in ACT effectiveness. We assessed optimum use of ACTs at the population level, specifically focusing on a strategy of multiple first-line therapies (MFT), and comparing it with strategies of cycling or sequential use of single first-line ACTs.

Methods

With an individual-based microsimulation of regional malaria transmission, we looked at how to apply a therapy as widely as possible without accelerating re

SUBMITTER: Nguyen TD 

PROVIDER: S-EPMC4641185 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature