Descriptive epidemiology of hereditary musculoskeletal and limb defects in the isolated population of Chitral, North-West Pakistan.

ABSTRACT:

Objectives

Musculoskeletal and limb defects (MLDs) are the major categories in hereditary anomalies and are a significant source of the disabilities. This study aimed at elucidating the nature and pattern of MLDs prevalent in Chitral district, which is an isolated population in the North-West of Pakistan.

Methods

A cross-sectional epidemiological study was conducted in Chitral and subjects/families with MLDs were ascertained from public places, hospitals and door-to-door visits. The phenotypic manifestations, expressivity, sporadic/familial presentations, isolated/syndromic nature, inheritance pattern, and socio-demographic attributes, of MLDs were observed.

Results

A total of 153 independent subjects/families with certain types of MLDs were recruited. The MLDs were c

SUBMITTER: Ullah S 

PROVIDER: S-EPMC4641253 | biostudies-literature | 2015 Sep-Oct

REPOSITORIES: biostudies-literature