Integrative enrichment analysis: a new computational method to detect dysregulated pathways in heterogeneous samples.

ABSTRACT:

Background

Pathway enrichment analysis is a useful tool to study biology and biomedicine, due to its functional screening on well-defined biological procedures rather than separate molecules. The measurement of malfunctions of pathways with a phenotype change, e.g., from normal to diseased, is the key issue when applying enrichment analysis on a pathway. The differentially expressed genes (DEGs) are widely focused in conventional analysis, which is based on the great purity of samples. However, the disease samples are usually heterogeneous, so that, the genes with great differential expression variance (DEVGs) are becoming attractive and important to indicate the specific state of a biological system. In the context of differential expression variance, it is still a challenge to me

SUBMITTER: Yu X 

PROVIDER: S-EPMC4641376 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature