A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

ABSTRACT: By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.

SUBMITTER: Shirani H 

PROVIDER: S-EPMC4641461 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature