Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes.

ABSTRACT:

Aims/hypothesis

Individuals with heterozygous activating mutations of the KCNJ11 gene encoding a subunit of the ATP-sensitive potassium channel (KATP) can usually be treated with oral sulfonylurea (SU) pills in lieu of insulin injections. The aim of this study was to test our hypothesis that younger age at the time of initiation of SU therapy is correlated with lower required doses of SU therapy, shorter transition time and decreased likelihood of requiring additional diabetes medications.

Methods

We performed a retrospective cohort study using data on 58 individuals with neonatal diabetes due to KCNJ11 mutations identified through the University of Chicago Monogenic Diabetes Registry ( http://monogenicdiabetes.uchicago.edu/registry ). We assessed the influence of age at ini

SUBMITTER: Thurber BW 

PROVIDER: S-EPMC4641523 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature