Gene Network Rewiring to Study Melanoma Stage Progression and Elements Essential for Driving Melanoma.

ABSTRACT: Metastatic melanoma patients have a poor prognosis, mainly attributable to the underlying heterogeneity in melanoma driver genes and altered gene expression profiles. These characteristics of melanoma also make the development of drugs and identification of novel drug targets for metastatic melanoma a daunting task. Systems biology offers an alternative approach to re-explore the genes or gene sets that display dysregulated behaviour without being differentially expressed. In this study, we have performed systems biology studies to enhance our knowledge about the conserved property of disease genes or gene sets among mutually exclusive datasets representing melanoma progression. We meta-analysed 642 microarray samples to generate melanoma reconstructed networks representing four different

SUBMITTER: Kaushik A 

PROVIDER: S-EPMC4641706 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature