Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects.

ABSTRACT:

Background

Statins substantially reduce cardiovascular mortality and appear to have beneficial effects independent of their lipid-lowering properties. We evaluated the hypothesis that statin use may modulate the secretion of aldosterone, a well-known contributor to cardiovascular disease.

Methods and results

We measured adrenal hormones in 2 intervention studies. In study 1 in hypertensive subjects, aldosterone was analyzed at baseline and after angiotensin II stimulation on both high- and low-sodium diets (1122 observations, 15% on statins for >3 months). Statin users had 33% lower aldosterone levels in adjusted models (P<0.001). Cortisol was not modified by statins. In secondary analyses, the lowest aldosterone levels were seen with lipophilic statins and with higher doses

SUBMITTER: Baudrand R 

PROVIDER: S-EPMC4641753 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature