A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics.

ABSTRACT:

Context and objective

We examined whether a prevalent caveolin-1 gene (CAV1) variant, previously related to insulin resistance, is associated with metabolic syndrome (MetS).

Patients and methods

We included subjects genotyped for the CAV1 variant rs926198 from two cohorts: 735 Caucasians from the HyperPATH multicenter study, and 810 Hispanic participants from the HTN-IR cohort.

Results

Minor allele carriers from HyperPATH cohort (57% of subjects) had higher Framingham risk scores, higher odds of diabetes (10.7% vs 5.7%, p=0.016), insulin resistance (44.3% vs 35.1%, p=0.022), low HDL (49.3% vs 39.6%, p=0.018) and MetS (33% vs 20.5%, p<0.001) but similar BMI. Consistently, minor allele carriers exhibited higher odds of MetS, even when adjusted for confounders and relate

SUBMITTER: Baudrand R 

PROVIDER: S-EPMC4641791 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature