IgE Antibody Detection and Component Analysis in Patients with Eosinophilic Esophagitis.

ABSTRACT:

Background

Although IgE antibodies to cow's milk and wheat are common in patients with eosinophilic esophagitis (EoE), titers are low and responses to diet are not dependent on having IgE antibodies.

Objective

To better define specific IgE antibody responses to foods, focusing on those foods that appear to play a role in EoE.

Methods

Adult (n = 46) and pediatric (n = 51) patients with EoE were recruited for skin prick testing and serum measurement (whole and diluted) of IgE antibodies specific for aeroallergens, food extracts, and component allergens by ImmunoCAP. Immuno Solid-phase Allergen Chip analysis was also used to measure the specificity of IgE antibodies to 112 allergen molecules.

Results

In adults and children, there was a higher prevalence of sensiti

SUBMITTER: Erwin EA 

PROVIDER: S-EPMC4641808 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature