Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort.

ABSTRACT:

Background

The objective of this study was to identify treatment and genetic factors associated with obesity among childhood cancer survivors.

Methods

Participants included 1996 survivors who previously received treatment for cancer at St. Jude Children's Research Hospital and who survived ≥10 years from diagnosis (median age at diagnosis, 7.2 years; median age at follow-up, 32.4 years). Obesity was defined as a body mass index ≥30 kg/m(2) . The factors associated with adult obesity were identified by subgroup-specific (cranial radiation [CRT] exposure status) multivariable logistic regression. Single nucleotide polymorphisms (SNPs) associated with obesity were identified by subgroup-specific, exploratory, genome-wide association analyses using a 2-stage resampling approach

SUBMITTER: Wilson CL 

PROVIDER: S-EPMC4641835 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature