Association of Lp-PLA2-A and early recurrence of vascular events after TIA and minor stroke.

ABSTRACT:

Objective

To determine the association of lipoprotein-associated phospholipase A2 (Lp-PLA2) measured in the acute period and the short-term risk of recurrent vascular events in patients with TIA or minor stroke.

Methods

We measured Lp-PLA2 activity (Lp-PLA2-A) in a subset of 3,201 participants enrolled in the CHANCE (Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events) trial. Participants with TIA or minor stroke were enrolled within 24 hours of symptom onset and randomized to single or dual antiplatelet therapy. In the current analysis, the primary outcome was defined as the composite of ischemic stroke, myocardial infarction, or death within 90 days.

Results

The composite endpoint occurred in 299 of 3,021 participants (9.9%). The popula

SUBMITTER: Lin J 

PROVIDER: S-EPMC4642142 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature