Cerebral small vessel disease and incident parkinsonism: The RUN DMC study.

ABSTRACT:

Objective

To investigate the relation between baseline cerebral small vessel disease (SVD) and the risk of incident parkinsonism using different MRI and diffusion tensor imaging (DTI) measures.

Methods

In the Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) study, a prospective cohort study, 503 elderly participants with SVD and without parkinsonism were included in 2006. During follow-up (2011-2012), parkinsonism was diagnosed according to UK Brain Bank criteria. Cox regression analysis was used to investigate the association between baseline imaging measures and incident all-cause parkinsonism and vascular parkinsonism (VP). Tract-based spatial statistics analysis was used to identify differences in baseline DTI measures of white matter

SUBMITTER: van der Holst HM 

PROVIDER: S-EPMC4642143 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature