Vitamins in pancreatic cancer: a review of underlying mechanisms and future applications.

ABSTRACT: Although there is increasing evidence that vitamins influence pancreatic adenocarcinoma biology and carcinogenesis, a comprehensive review is lacking. In this study, we performed a PubMed literature search to review the anticancer mechanisms and the preclinical and clinical studies that support the development of the bioactive vitamins A, C, D, E, and K in pancreatic cancer intervention. Preclinical studies have shown promising results for vitamin A in pancreatic cancer prevention, with clinical trials showing intriguing responses in combination with immunotherapy. For vitamin C, preclinical studies have shown slower tumor growth rates and/or increased survival when used alone or in combination with gemcitabine, with clinical trials with this combination revealing decreased primary tumor s

SUBMITTER: Davis-Yadley AH 

PROVIDER: S-EPMC4642423 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature