Label-Free Biosensing with High Selectivity in Complex Media using Microtoroidal Optical Resonators.

ABSTRACT: Although label-free biosensors comprised of optical microcavities inherently possess the capability of resolving molecular interactions at individual level, this extreme sensitivity restricts their convenience for large scale applications by inducing vulnerability towards non-specific interactions that readily occur within complex media. Therefore, the use of optical microresonators for biosensing is mostly limited within strictly defined laboratory conditions, instead of field applications as early detection of cancer markers in blood, or identification of contamination in food. Here, we propose a novel surface modification strategy suitable for but not limited to optical microresonator based biosensors, enabling highly selective biosensing with considerable sensitivity as well. Using a r

SUBMITTER: Ozgur E 

PROVIDER: S-EPMC4642504 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature