IL-11 induces differentiation of myeloid-derived suppressor cells through activation of STAT3 signalling pathway.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are immune negative regulators in the tumour microenvironment. Interleukin (IL)-11, a member of IL-6 family cytokines, functions through the unique receptor IL-11 receptor α coupled with the common signal transducer gp130. IL-11-gp130 signalling causes activation of the JAK/STAT3 pathway. IL-11 is highly upregulated in many types of cancers and one of the most important cytokines during tumourigenesis and metastasis. However, the precise effect of IL-11 on differentiation into MDSCs is still unknown. Here, we found that CD11b⁺CD14⁺ monocytic MDSCs were generated from peripheral blood mononuclear cells (PBMCs) of healthy donors in the presence of IL-11. IL-11-conditioned PBMCs induced higher expression of immunosuppressive molec

SUBMITTER: Sumida K 

PROVIDER: S-EPMC4642551 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature