Tissue-specific transcriptomics and proteomics of a filarial nematode and its Wolbachia endosymbiont.

ABSTRACT:

Background

Filarial nematodes cause debilitating human diseases. While treatable, recent evidence suggests drug resistance is developing, necessitating the development of novel targets and new treatment options. Although transcriptomic and proteomic studies around the nematode life cycle have greatly enhanced our knowledge, whole organism approaches have not provided spatial resolution of gene expression, which can be gained by examining individual tissues. Generally, due to their small size, tissue dissection of human-infecting filarial nematodes remains extremely challenging. However, canine heartworm disease is caused by a closely related and much larger filarial nematode, Dirofilaria immitis. As with many other filarial nematodes, D. immitis contains Wolbachia, an obligate bact

SUBMITTER: Luck AN 

PROVIDER: S-EPMC4642636 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature