Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.

ABSTRACT:

Background

Disseminated tumor cells (DTCs) can be detected using ultrasensitive immunocytochemical assays and their presence in the bone marrow can predict the subsequent occurrence of overt metastasis formation and metastatic relapse. Using expression profiling on early stage primary breast tumors, low IRX2 expression was previously shown to be associated with the presence of DTCs in the bone marrow, suggesting a possible role of IRX2 in the early steps of metastasis formation. The purpose of this study is to gain insights into the significance of IRX2 protein function in the progression of breast cancer.

Methods

To assess the physiological relevance of IRX2 in breast cancer, we evaluated IRX2 expression in a large breast cancer cohort (n = 1992). Additionally, constitutive

SUBMITTER: Werner S 

PROVIDER: S-EPMC4642646 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature