Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level.

ABSTRACT:

Purpose

Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels.

Materials and methods

We examined associations between single nucleotide polymorphisms on chromosomes 10 and 19 (previously shown to be associated with prostate specific antigen) with prostate specific antigen and prostate cancer in 505 men from the Baltimore Longitudinal Study of Aging.

Results

In a model with age and date the risk ratio for prostate cancer was 1.18 (95% CI 1.13-1.23) per unit increase in prostate specific antigen. Including the interaction between alleles and prostate specific antigen significantly altered the risk ratio for prostate cancer (Cox pro

SUBMITTER: Loeb S 

PROVIDER: S-EPMC4642710 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature