Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.

ABSTRACT:

Objective

Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological studies. Since vitamin D is also implicated in vascular protection and affects IGF-1 biology, we hypothesized that it would influence the effect of IGF-1 on IMT.

Methods

The relationship between carotid IMT and fasting serum IGF-1 was examined across strata of 25-hydroxyvitamin D [25(OH)D] in 472 participants in the Baltimore Longitudinal Study of Aging (BLSA) with well-controlled blood pressure and in 165 treatment-naive patients with essential hypertension fro

SUBMITTER: Ameri P 

PROVIDER: S-EPMC4642711 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature