Tissue Distribution of Memory T and B Cells in Rhesus Monkeys following Influenza A Infection.

ABSTRACT: Studies of influenza-specific immune responses in humans have largely assessed systemic responses involving serum Ab and peripheral blood T cell responses. However, recent evidence indicates that tissue-resident memory T (TRM) cells play an important role in local murine intrapulmonary immunity. Rhesus monkeys were pulmonary exposed to 2009 pandemic H1N1 virus at days 0 and 28 and immune responses in different tissue compartments were measured. All animals were asymptomatic postinfection. Although only minimal memory immune responses were detected in peripheral blood, a high frequency of influenza nucleoprotein-specific memory T cells was detected in the lung at the "contraction phase," 49-58 d after second virus inoculation. A substantial proportion of lung nucleoprotein-specific memory C

SUBMITTER: Pichyangkul S 

PROVIDER: S-EPMC4642841 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature