Following specific podocyte injury captopril protects against progressive long term renal damage.

ABSTRACT:

Background

Angiotensin converting enzyme inhibitors (ACEi) reduce proteinuria and preserve kidney function in proteinuric renal diseases. Their nephroprotective effect exceeds that attributable to lowering of blood pressure alone. This study examines the potential of ACEi to protect from progression of injury after a highly specific injury to podocytes in a mouse model.

Methods

We created transgenic (Podo-DTR) mice in which graded specific podocyte injury could be induced by a single injection of diphtheria toxin. Transgenic and wild-type mice were given the ACEi captopril in drinking water, or water alone, commencing 24h after toxin injection. Kidneys were examined histologically at 8 weeks and injury assessed by observers blinded to experimental group.

Results

After

SUBMITTER: Zhou YS 

PROVIDER: S-EPMC4642846 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature