Enantioselective ortho-C-H cross-coupling of diarylmethylamines with organoborons.

ABSTRACT: The commonly used para-nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation of amines for the first time. An enantioselective ortho-CH cross-coupling between nosyl-protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono-N-protected amino acid (MPAA) ligands as a promoter.

SUBMITTER: Laforteza BN 

PROVIDER: S-EPMC4642891 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature