From System-Wide Differential Gene Expression to Perturbed Regulatory Factors: A Combinatorial Approach.

ABSTRACT: High-throughput experiments such as microarrays and deep sequencing provide large scale information on the pattern of gene expression, which undergoes extensive remodeling as the cell dynamically responds to varying environmental cues or has its function disrupted under pathological conditions. An important initial step in the systematic analysis and interpretation of genome-scale expression alteration involves identification of a set of perturbed transcriptional regulators whose differential activity can provide a proximate hypothesis to account for these transcriptomic changes. In the present work, we propose an unbiased and logically natural approach to transcription factor enrichment. It involves overlaying a list of experimentally determined differentially expressed genes on a backgro

SUBMITTER: Mahajan G 

PROVIDER: S-EPMC4642966 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature