Bouvardin is a Radiation Modulator with a Novel Mechanism of Action.

ABSTRACT: Protein synthesis is essential for growth, proliferation and survival of cells. Translation factors are overexpressed in many cancers and in preclinical models, their experimental inhibition has been shown to inhibit cancer growth. Differential regulation of translation also occurs upon exposure to cancer-relevant stressors such as hypoxia and ionizing radiation. The failure to regulate translation has been shown to interfere with recovery after genotoxic stress. These findings suggest that modulation of translation, alone or in conjunction with genotoxins, may be therapeutic in oncology. Yet, only two drugs that directly inhibit translation are FDA-approved for oncology therapies used today. We have previously identified the protein synthesis inhibitor, bouvardin in a screen for small mol

SUBMITTER: Stickel SA 

PROVIDER: S-EPMC4643058 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature