A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas.

ABSTRACT:

Background

Epidemiologic and preclinical data suggest that higher intake and serum levels of vitamin D and higher intake of calcium reduce the risk of colorectal neoplasia. To further study the chemopreventive potential of these nutrients, we conducted a randomized, double-blind, placebo-controlled trial of supplementation with vitamin D, calcium, or both for the prevention of colorectal adenomas.

Methods

We recruited patients with recently diagnosed adenomas and no known colorectal polyps remaining after complete colonoscopy. We randomly assigned 2259 participants to receive daily vitamin D3 (1000 IU), calcium as carbonate (1200 mg), both, or neither in a partial 2×2 factorial design. Women could elect to receive calcium plus random assignment to vitamin D or placebo. Follo

SUBMITTER: Baron JA 

PROVIDER: S-EPMC4643064 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature