A longitudinal model for disease progression was developed and applied to multiple sclerosis.

ABSTRACT:

Objectives

To develop a model of disease progression using multiple sclerosis (MS) as an exemplar.

Study design and settings

Two observational cohorts, the University of Wales MS (UoWMS), UK (1976), and British Columbia MS (BCMS) database, Canada (1980), with longitudinal disability data [the Expanded Disability Status Scale (EDSS)] were used; individuals potentially eligible for MS disease-modifying drugs treatments, but who were unexposed, were selected. Multilevel modeling was used to estimate the EDSS trajectory over time in one data set and validated in the other; challenges addressed included the choice and function of time axis, complex observation-level variation, adjustments for MS relapses, and autocorrelation.

Results

The best-fitting model for the UoWMS co

SUBMITTER: Lawton M 

PROVIDER: S-EPMC4643305 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature