Genetic Predictors of Depressive Symptoms in the Look AHEAD Trial.

ABSTRACT:

Objectives

Numerous studies have found elevated depressive symptoms among individuals with Type 2 diabetes, yet the mechanisms remain unclear. We examined whether genetic loci previously associated with depressive symptoms predict depressive symptoms among overweight/obese individuals with Type 2 diabetes or change in depressive symptoms during behavioral weight loss.

Methods

The Illumina CARe iSelect (IBC) chip and Cardiometabochip were characterized in 2118 overweight or obese participants with Type 2 diabetes from Look AHEAD (Action for Health in Diabetes), a randomized trial to determine the effects of intensive life-style intervention and diabetes support and education on cardiovascular morbidity and mortality. Primary analyses focused on baseline Beck Depression Invent

SUBMITTER: McCaffery JM 

PROVIDER: S-EPMC4643359 | biostudies-literature | 2015 Nov-Dec

REPOSITORIES: biostudies-literature