Ontology highlight
ABSTRACT:
SUBMITTER: Pradeep S
PROVIDER: S-EPMC4643364 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cancer cell 20151017 5
While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo's effects on cancer cells prompted us to consider the existence of an alternative Epo receptor. Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression. In human ov ...[more]