Systematic review of interventional sickle cell trials registered in ClinicalTrials.gov.

ABSTRACT:

Background/aims

The registry ClinicalTrials.gov was created to provide investigators and patients an accessible database of relevant clinical trials.

Methods

To understand the state of sickle cell disease clinical trials, a comprehensive review of all 174 "closed," "interventional" sickle cell trials registered at ClinicalTrials.gov was completed in January 2015.

Results

The majority of registered sickle cell disease clinical trials listed an academic center as the primary sponsor and were an early phase trial. The primary outcome for sickle cell disease trials focused on pain (23%), bone marrow transplant (BMT) (13%), hydroxyurea (8%), iron overload (8%), and pulmonary hypertension (8%). A total of 52 trials were listed as terminated or withdrawn, including 25 (14% o

SUBMITTER: Lebensburger JD 

PROVIDER: S-EPMC4643416 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature