Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis.

ABSTRACT:

Study question

Are microRNAs (miRs) altered in the eutopic endometrium (EuE) of baboons following the induction of endometriosis?

Summary answer

Induction of endometriosis causes significant changes in the expression of eight miRs, including miR-451, in the baboon endometrium as early as 3 months following induction of the disease.

What is known already

Endometriosis is one of the most common gynecological disorders and causes chronic pelvic pain and infertility in women of reproductive age. Altered expression of miRs has been reported in women and has been suggested to play an important role in the pathophysiology of several gynecological disorders including endometriosis.

Study design, size, duration

EuE was obtained from the same group of baboons before and

SUBMITTER: Joshi NR 

PROVIDER: S-EPMC4643526 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature