Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use.

ABSTRACT:

Background

Serum markers of inflammation increase with age and have been strongly associated with adverse clinical outcomes among both HIV-infected and uninfected adults. Yet, limited data exist on the predictive and clinical utility of aggregate measures of inflammation. This study sought to evaluate the relationship of a recently validated aggregate inflammatory index with frailty and mortality among aging HIV-infected and uninfected injection drug users.

Methods

Frailty was assessed among HIV-infected and uninfected participants in the AIDS Linked to the IntraVenous Experience (ALIVE) cohort study using the five Fried phenotypic criteria: weight loss, exhaustion, low physical activity, decreased grip strength, and slow gait. The aggregate inflammatory index was constructe

SUBMITTER: Piggott DA 

PROVIDER: S-EPMC4643614 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature