Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization.

ABSTRACT:

Background

Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.

Methods

We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control patients, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data fr

SUBMITTER: Zhang B 

PROVIDER: S-EPMC4643630 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature