Integrative pathway genomics of lung function and airflow obstruction.

ABSTRACT: Chronic respiratory disorders are important contributors to the global burden of disease. Genome-wide association studies (GWASs) of lung function measures have identified several trait-associated loci, but explain only a modest portion of the phenotypic variability. We postulated that integrating pathway-based methods with GWASs of pulmonary function and airflow obstruction would identify a broader repertoire of genes and processes influencing these traits. We performed two independent GWASs of lung function and applied gene set enrichment analysis to one of the studies and validated the results using the second GWAS. We identified 131 significantly enriched gene sets associated with lung function and clustered them into larger biological modules involved in diverse processes including de

SUBMITTER: Gharib SA 

PROVIDER: S-EPMC4643644 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature