Differential N-Glycosylation Patterns in Lung Adenocarcinoma Tissue.

ABSTRACT: To decrease the mortality of lung cancer, better screening and diagnostic tools as well as treatment options are needed. Protein glycosylation is one of the major post-translational modifications that is altered in cancer, but it is not exactly clear which glycan structures are affected. A better understanding of the glycan structures that are differentially regulated in lung tumor tissue is highly desirable and will allow us to gain greater insight into the underlying biological mechanisms of aberrant glycosylation in lung cancer. Here, we assess differential glycosylation patterns of lung tumor tissue and nonmalignant tissue at the level of individual glycan structures using nLC-chip-TOF-MS. Using tissue samples from 42 lung adenocarcinoma patients, 29 differentially expressed (FDR < 0.0

SUBMITTER: Ruhaak LR 

PROVIDER: S-EPMC4644186 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature