Dataset Information

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

ABSTRACT: Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-positive, and mutant KRAS, EGFR, or PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based "liquid biopsies".

SUBMITTER: Best MG

PROVIDER: S-EPMC4644263 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Best Myron G MG Sol Nik N Kooi Irsan I Tannous Jihane J Westerman Bart A BA Rustenburg François F Schellen Pepijn P Verschueren Heleen H Post Edward E Koster Jan J Ylstra Bauke B Ameziane Najim N Dorsman Josephine J Smit Egbert F EF Verheul Henk M HM Noske David P DP Reijneveld Jaap C JC Nilsson R Jonas A RJA Tannous Bakhos A BA Wesseling Pieter P Wesseling Pieter P Wurdinger Thomas T

Cancer cell 20151029 5

Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-po ...[more]

PMID: 26525104

Dataset Information

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Publications

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Similar Datasets

RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass and molecular pathway cancer diagnostics
2015-10-30 | E-GEOD-68086 | biostudies-arrayexpress

RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass and molecular pathway cancer diagnostics
2015-10-30 | GSE68086 | GEO

RNA-Sequencing of Tumor-Educated Platelets, a Novel Biomarker for Blood-Based Sarcoma Diagnostics.
| S-EPMC7352477 | biostudies-literature

Development and Validation of Tumor-educated Blood Platelets Integrin Alpha 2b (ITGA2B) RNA for Diagnosis and Prognosis of Non-small-cell Lung Cancer through RNA-seq.
| S-EPMC6743295 | biostudies-literature

Identification of seven tumor-educated platelets RNAs for cancer diagnosis.
| S-EPMC8183939 | biostudies-literature

Tumour-educated platelets for breast cancer detection: biological and technical insights.
| S-EPMC10070267 | biostudies-literature

Identifying and analyzing different cancer subtypes using RNA-seq data of blood platelets.
| S-EPMC5675649 | biostudies-literature

Biotech-Educated Platelets: Beyond Tissue Regeneration 2.0.
| S-EPMC7503652 | biostudies-literature

Complex Age- and Cancer-Related Changes in Human Blood Transcriptome-Implications for Pan-Cancer Diagnostics.
| S-EPMC8554330 | biostudies-literature

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding.
| S-EPMC8678193 | biostudies-literature