Dataset Information

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

ABSTRACT: Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-positive, and mutant KRAS, EGFR, or PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based "liquid biopsies".

SUBMITTER: Best MG

PROVIDER: S-EPMC4644263 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Best Myron G MG Sol Nik N Kooi Irsan I Tannous Jihane J Westerman Bart A BA Rustenburg François F Schellen Pepijn P Verschueren Heleen H Post Edward E Koster Jan J Ylstra Bauke B Ameziane Najim N Dorsman Josephine J Smit Egbert F EF Verheul Henk M HM Noske David P DP Reijneveld Jaap C JC Nilsson R Jonas A RJA Tannous Bakhos A BA Wesseling Pieter P Wesseling Pieter P Wurdinger Thomas T

Cancer cell 20151029 5

Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-po ...[more]

PMID: 26525104

Dataset Information

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

Publications

RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics.

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