Persistent androgen receptor addiction in castration-resistant prostate cancer.

ABSTRACT: It is now understood that persistent activation of the androgen receptor (AR) signaling pathway often underlies the development of castration-resistant prostate cancer (CRPC). This realization led to renewed interest in targeting the AR and ultimately to the development of the potent next-generation AR-directed agents abiraterone and enzalutamide. While these drugs prolong survival in men with CRPC, they are unfortunately not curative. Perhaps not surprisingly, evidence points to persistent AR signaling as one of the key drivers by which resistances to these agents develops. In this context, activation of the AR signaling program can occur through a number of molecular adaptations, including alterations leading to persistent canonical AR signaling (e.g., AR amplification/overexpression, el

SUBMITTER: Schweizer MT 

PROVIDER: S-EPMC4644296 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature