Characterization and quantification of proteins secreted by single human embryos prior to implantation.

ABSTRACT: The use of in vitro fertilization (IVF) has revolutionized the treatment of infertility and is now responsible for 1-5% of all births in industrialized countries. During IVF, it is typical for patients to generate multiple embryos. However, only a small proportion of them possess the genetic and metabolic requirements needed in order to produce a healthy pregnancy. The identification of the embryo with the greatest developmental capacity represents a major challenge for fertility clinics. Current methods for the assessment of embryo competence are proven inefficient, and the inadvertent transfer of non-viable embryos is the principal reason why most IVF treatments (approximately two-thirds) end in failure. In this study, we investigate how the application of proteomic measurements could im

SUBMITTER: Poli M 

PROVIDER: S-EPMC4644378 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature