Shared additive genetic influences on DSM-IV criteria for alcohol dependence in subjects of European ancestry.

ABSTRACT:

Background and aims

Genetic studies of alcohol dependence (AD) have identified several candidate loci and genes, but most observed effects are small and difficult to reproduce. A plausible explanation for inconsistent findings may be a violation of the assumption that genetic factors contributing to each of the seven DSM-IV criteria point to a single underlying dimension of risk. Given that recent twin studies suggest that the genetic architecture of AD is complex and probably involves multiple discrete genetic factors, the current study employed common single nucleotide polymorphisms in two multivariate genetic models to examine the assumption that the genetic risk underlying DSM-IV AD is unitary.

Design, setting, participants, measurements

AD symptoms and genome-wide singl

SUBMITTER: Palmer RH 

PROVIDER: S-EPMC4644467 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature