FAS and FAS-Ligand Promoter Polymorphisms in Hepatitis B Virus Infection.

ABSTRACT:

Background

The FAS and FAS-Ligand (FASL) system is an important apoptosis pathway in the liver. The FAS-mediated pathway functions by binding the FASL on the activated cytotoxic T lymphocytes and Natural Killer (NK) cells to the FAS receptor on infected hepatocytes. FAS and FASL polymorphisms, which are related to apoptosis, might influence the outcome of Hepatitis B Virus (HBV) infection.

Objectives

Thus, the present study aimed to determine if FAS and FASL promoter polymorphisms are associated with the clinical outcome of HBV infection.

Patients and methods

DNA samples were obtained from the infected individuals including chronic carrier (n = 50), chronic hepatitis (n = 50), cirrhosis (n = 25), naturally recovered (n = 26) and compared with those of their matched he

SUBMITTER: Mohammadi A 

PROVIDER: S-EPMC4644599 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature