Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury-Related Mortality: Interrelationships Between Genetics and Acute Systemic and Central Nervous System BDNF Profiles.

ABSTRACT:

Background

Older adults have higher mortality rates after severe traumatic brain injury (TBI) compared to younger adults. Brain-derived neurotrophic factor (BDNF) signaling is altered in aging and is important to TBI given its role in neuronal survival/plasticity and autonomic function. Following experimental TBI, acute BDNF administration has not been efficacious. Clinically, genetic variation in BDNF (reduced signaling alleles: rs6265, Met-carriers; rs7124442, C-carriers) can be protective against acute mortality. Postacutely, these genotypes carry lower mortality risk in older adults and greater mortality risk among younger adults.

Objective

Investigate BDNF levels in mortality/outcome following severe TBI in the context of age and genetic risk.

Methods

Cerebrospin

SUBMITTER: Failla MD 

PROVIDER: S-EPMC4644728 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature