Pathologically confirmed autoimmune encephalitis in suspected Creutzfeldt-Jakob disease.

ABSTRACT:

Objective

To determine the clinical features and presence in CSF of antineuronal antibodies in patients with pathologically proven autoimmune encephalitis derived from a cohort of patients with suspected Creutzfeldt-Jakob disease (CJD).

Methods

The Dutch Surveillance Centre for Prion Diseases performed 384 autopsies on patients with suspected CJD over a 14-year period (1998-2011). Clinical information was collected from treating physicians. Antineuronal antibodies were tested in CSF obtained postmortem by immunohistochemistry on fresh frozen rat brain sections, by Luminex assay for the presence of well-characterized onconeural antibodies, and by cell-based assays for antibodies against NMDAR, GABABR1/2, GABAAR GLUR1/2, LGI1, Caspr2, and DPPX.

Results

In 203 patients,

SUBMITTER: Maat P 

PROVIDER: S-EPMC4645173 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature