Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.

ABSTRACT:

Unlabelled

The HIV-1 accessory protein Vpr displays different activities potentially impacting viral replication, including the arrest of the cell cycle in the G2 phase and the stimulation of apoptosis and DNA damage response pathways. Vpr also modulates cytokine production by infected cells, but this property remains partly characterized. Here, we investigated the effect of Vpr on the production of the proinflammatory cytokine tumor necrosis factor (TNF). We report that Vpr significantly increases TNF secretion by infected lymphocytes. De novo production of Vpr is required for this effect. Vpr mutants known to be defective for G2 cell cycle arrest induce lower levels of TNF secretion, suggesting a link between these two functions. Silencing experiments and the use of chemical inhi

SUBMITTER: Roesch F 

PROVIDER: S-EPMC4645299 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature