Cost effectiveness of collagen crosslinking for progressive keratoconus in the UK NHS.

ABSTRACT:

Background

Keratoconus is a progressive degenerative corneal disorder of children and young adults that is traditionally managed by refractive error correction, with corneal transplantation reserved for the most severe cases. UVA collagen crosslinking is a novel procedure that aims to prevent disease progression, currently being considered for use in the UK NHS. We assess whether it might be a cost-effective alternative to standard management for patients with progressive keratoconus.

Methods

We constructed a Markov model in which we estimated disease progression from prospective follow-up studies, derived costs derived from the NHS National Tariff, and calculated utilities from linear regression models of visual acuity in the better-seeing eye. We performed deterministic an

SUBMITTER: Salmon HA 

PROVIDER: S-EPMC4645452 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature