The incretin effect in critically ill patients: a case-control study.

ABSTRACT:

Introduction

Patients admitted to the intensive care unit often develop hyperglycaemia, but the underlying mechanisms have not been fully described. The incretin effect is reduced in patients with type 2 diabetes. Type 2 diabetes and critical illness have phenotypical similarities, such as hyperglycaemia, insulin resistance and systemic inflammation. Previous studies have shown beneficial effects of exogenous glucagon-like peptide (GLP)-1 on glycaemia in critically ill patients, a phenomenon also seen in patients with type 2 diabetes. In this study, we hypothesised that the incretin effect, which is mediated by the incretin hormones GLP-1 and glucose-dependent insulinotropic peptide (GIP), is impaired in critically ill patients.

Methods

The incretin effect (i.e., the relativ

SUBMITTER: Nielsen ST 

PROVIDER: S-EPMC4645481 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature